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Cialis dosage for prostate cancer patients who are being treated with other drugs.
The article, published in journal JAMA Oncology, analyzed data from a trial of the drug, which was halted in 2015 when it was found to also increase the risk of death among men with aggressive prostate cancer.
A team of researchers led by Dr. Robert West of the University Melbourne, Australia, used data from the U.S. clinical trial to estimate whether there was a relationship between the use of levitra and an increased risk of death.
They based their findings on a "predictor" analysis that is statistical technique used to identify risk factors in order to determine if there is a correlation between exposure to and outcomes, according the article's abstract. researchers said a larger study was needed to determine whether levitra might cause an increased risk of death.
In the U.S. trial, all 694 men who had been treated with the drug received same course of treatment, in addition to standard care. Although there was no increase in the rate of death among those who received the drug, researchers found that these patients were 20 percent more likely to die if they also received a course of radiation therapy, compared with those receiving standard therapy.
West said he is aware of no other studies that have evaluated the effect of levitra on prostate cancer patients and the results of this study are consistent with other reports of increased risk.
"In the U.S., prostate cancer is second most common cause of cancer death in men," he told Reuters Health by email. "The number of deaths caused by prostate cancer has been on a steady downward trend for about 15 years, and is now about half of what it was a decade ago."
Levitra, which is a part of the drug cialis generika kaufen rezeptfrei bestellen Cialis, is used to treat erectile dysfunction in men who are having difficulties reaching an orgasm. Some men also take it to deal with fatigue due the aging process. Levitra is considered the drug of choice in Australia, according to the abstract.
West said it is unclear why levitra might trigger an increased risk of death in men with prostate cancer.
"The most likely scenario is that the high dose given to these patients during the course of treatment is causing some sort of toxic effect on the prostate," he said. "This does not explain why the higher use of levitra during the course treatment would increase cancer-related death at all, but is a possibility worth consideration."
West said levitra is approved by the FDA for treatment of erectile dysfunction, but Buy adapalene gel
the association between levitra and increased risk of death was unexpected.
"This is a relatively large and well-controlled study, so it was surprising to find a strong effect of levitra on mortality when was used in what seemed to be a low-dose regimen compared with other anti-aging drugs," he said.
West said the study is important to clinicians because it sheds light on a potentially important cause of death in prostate cancer patients and to researchers because it makes possible for them to link higher use of levitra during the course treatment with an increased risk of death, he said.
"It will be fascinating to see whether this effect is repeated in other trials of different anti-aging agents from other drugs, and whether this is also linked to other causes of death, such as heart disease or other causes of death," he said.
SOURCE: bit.ly/2kpEKq5 JAMA Oncology, online October 18, 2017.
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